Abstract: Shoulder pain is a common complaint in clinical practice, with various etiologies ranging from musculoskeletal disorders to systemic conditions. We present a case of Multiple myeloma (MM) in a 70-year-old male who presented with progressive right shoulder pain and weakness. Radiographic imaging revealed lytic lesion within the proximal humerus consistent with an aggresive disease. The patient underwent a comprehensive diagnostic workup, including serum protein electrophoresis, immunofixation, and bone marrow biopsy, confirming the diagnosis of MM. Treatment was initiated with prophylactic nailing along with combination of chemotherapy and bisphosphonates, resulting in symptomatic improvement and stabilization of disease progression. This case underscores the importance of considering MM as a differential diagnosis in patients presenting with bone pain and emphasizes the need for prompt diagnosis and multidisciplinary management to optimize patient outcomes.
